HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell
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چکیده
منابع مشابه
The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.
Progesterone, via the progesterone receptor (PGR), is essential for endometrial stromal cell decidualization, a cellular transformation event in which stromal fibroblasts differentiate into decidual cells. Uterine decidualization supports embryo implantation and placentation as well as subsequent events, which together ensure a successful pregnancy. Accordingly, impaired decidualization results...
متن کاملMicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
BACKGROUND The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we examined microRNA-181a (miR-181a) expression in decidualized human endometrial stromal cell (hESC). In addition, we investigated the functional effect of miR-18...
متن کاملEndometrial stromal beta-catenin is required for steroid-dependent mesenchymal-epithelial cross talk and decidualization
BACKGROUND Beta-catenin is part of a protein complex associated with adherens junctions. When allowed to accumulate to sufficient levels in its dephosphorylated form, beta-catenin serves as a transcriptional co-activator associated with a number of signaling pathways, including steroid hormone signaling pathways. METHODS To investigate the role of beta-catenin in progesterone (P₄) signaling a...
متن کاملRbbp7 Is Required for Uterine Stromal Decidualization in Mice.
Uterine stromal cells undergo extensive proliferation and differentiation during postimplantation development, a process known as decidualization. While a range of signaling molecules have been demonstrated to play essential roles in this event, its potential epigenetic regulatory mechanisms remain largely unknown. Retinoblastoma binding protein 7 (Rbbp7) is a protein reported as a core compone...
متن کاملChronic endometritis modifies decidualization in human endometrial stromal cells
BACKGROUND Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, u...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2020
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-19-0100